眼障害及び皮膚疾患の処置のための化合物、組成物、及び方法

• Format: Patent
• Language: Japanese
• Published: 12.02.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

眼障害、皮膚疾患、及び／又はそれらに関連する合併症の処置に有用な式Ｉの化合物、又はその薬学的に許容可能な水和物、溶媒和物、結晶、共結晶、鏡像異性体、立体異性体、多形、若しくはプロドラッグを開示する。活性成分として少なくとも１つの式Ｉの化合物と薬学的に許容可能な添加剤とを含む医薬組成物も開示する。少なくとも１つの式Ｉの化合物、又はその薬学的に許容可能な水和物、溶媒和物、結晶、共結晶、鏡像異性体、立体異性体、多形、若しくはプロドラッグを投与することによって、処置を必要とする被験体において眼障害、皮膚疾患、及び／又はそれらの合併症を処置する方法も開示する。【選択図】なし Disclosed is a compound of formula I or a pharmaceutically acceptable hydrate, solvate, crystal, co-crystal, enantiomer, stereoisomer, polymorph or prodrug thereof, which is useful for treatment of eye disorders, skin diseases and/or complications associated therewith. Also disclosed is a pharmaceutical composition comprising as an active ingredient at least one compound of formula I and a pharmaceutically acceptable excipient. Also disclosed is a method of treating an eye disorder, skin disease and/or a complication thereof in a subject in need thereof by administering at least one compound of formula I or a pharmaceutically acceptable hydrate, solvate, crystal, co-crystal, enantiomer, stereoisomer, polymorph or prodrug thereof.