ANTIBODIES BINDING TO HLA-A2/WT1

• Main Authors: LYDIA JASMIN HANISCH, CHRISTIAN KLEIN, JOHANNES SAM, JOERG BENZ, STEFAN KLOSTERMANN, ALEXANDER BUJOTZEK, XU WEI, MOESSNER EKKEHARD, PABLO UMANA
• Format: Patent
• Language: English; Japanese
• Published: 09.09.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide novel antibodies that bind to HLA-A2/WT1, have markedly useful properties for therapeutic purposes, and include bispecific antibodies.SOLUTION: The present disclosure provides an antibody that binds to HLA-A2/WT1, where the antibody binds to an epitope of HLA A2/WT1, particularly HLA-A2/WT1RMF, comprising at least three amino acid residues of the WT1 peptide in HLA-A2/WT1, particularly the WT1RMF peptide.SELECTED DRAWING: None 【課題】ＨＬＡ−Ａ２／ＷＴ１に結合し、治療目的に特に有利な特性を有する、二重特異性抗体を含む新規抗体を提供する。【解決手段】ＨＬＡ−Ａ２／ＷＴ１に結合する抗体であって、抗体は、ＨＬＡ−Ａ２／ＷＴ１のＷＴ１ペプチド、特にＷＴ１ＲＭＦペプチドの少なくとも３つのアミノ酸残基を含む、ＨＬＡ−Ａ２／ＷＴ１、特にＨＬＡ−Ａ２／ＷＴ１ＲＭＦのエピトープに結合する抗体。【選択図】なし