PHARMACEUTICAL COMPOSITIONS COMPRISING Akt PROTEIN KINASE INHIBITORS

• Main Authors: PETER STEIDLE, ANDRE HELL, REINHARD REENTS, MARTIN WUNDERLICH, PIRMIN HIDBER, MARIE PEPELNJAK, FRANCIS GOSSELIN, EDWARD YOST
• Format: Patent
• Language: English; Japanese
• Published: 19.08.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide pharmaceutical compositions comprising Akt protein kinase inhibitors with therapeutic activity against diseases such as cancer, as well as to provide methods for their preparation, and to provide their processes as medicament.SOLUTION: The Akt inhibitor is (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one(ipatasertib) or a pharmaceutically acceptable salt thereof.SELECTED DRAWING: Figure 1 【課題】がん等の疾患に対する治療活性を有するＡｋｔプロテインキナーゼ阻害剤を含む薬学的組成物、並びにそれらの調製のための方法及び医薬としてのそれらのプロセスに関する。【解決手段】Ａｋｔ阻害剤が、（Ｓ）−２−（４−クロロフェニル）−１−（４−（（５Ｒ，７Ｒ）−７−ヒドロキシ−５−メチル−６，７−ジヒドロ−５Ｈ−シクロペンタ［ｄ］ピリミジン−４−イル）ピペラジン−１−イル）−３−（イソプロピルアミノ）プロパン−１−オン（イパタセルチブ）又は薬学的に許容されるその塩。【選択図】図１