CYTIDINE-5-CARBOXAMIDE MODIFIED NUCLEOTIDE COMPOSITIONS AND METHODS RELATED THERETO
To provide 5-position modified cytosines and phosphoramidites thereof, and triphosphate derivatives thereof, and methods of making and using the same, and compositions and uses of the modified nucleosides as part of a nucleic acid molecule (e.g., aptamer).SOLUTION: The present disclosure provides a...
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Language | English Japanese |
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13.05.2021
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Abstract | To provide 5-position modified cytosines and phosphoramidites thereof, and triphosphate derivatives thereof, and methods of making and using the same, and compositions and uses of the modified nucleosides as part of a nucleic acid molecule (e.g., aptamer).SOLUTION: The present disclosure provides a compound having a structure represented by the following formula I. (R independently represents -(CH2) n-, n is an integer of 0-10; R' is independently selected from the group consisting of -H, -OAc, -OBz, -P(NiPr2)(OCH2CH2CN), and -OSiMe2 tBu; R'' is independently selected from the group consisting of hydrogen, 4,4'-dimethoxytrityl (DMT) and triphosphate (-P(O)(OH)-O-P(O)(OH)-O-P(O)(OH)2) or a salt thereof).SELECTED DRAWING: None
【課題】5位修飾シトシン及びそのホスホルアミダイト、ならびにトリホスフェート誘導体、それの製造及び使用方法、及び核酸分子(例えば、アプタマー)の一部としての組成物ならびに修飾ヌクレオシドの使用を提供する。【解決手段】下記式Iに示される構造を含む化合物。(Rは独立して−(CH2)n−であって、nは0〜10の整数であり;R'は−H、−OAc、−OBz、−P(NiPr2)(OCH2CH2CN)、及び−OSiMe2tBuから成る群から独立して選択され;R''は水素、4,4'−ジメトキシトリチル(DMT)及びトリホスフェート(−P(O)(OH)−O−P(O)(OH)−O−P(O)(OH)2)またはそれらの塩から成る群から独立して選択される。)【選択図】なし |
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AbstractList | To provide 5-position modified cytosines and phosphoramidites thereof, and triphosphate derivatives thereof, and methods of making and using the same, and compositions and uses of the modified nucleosides as part of a nucleic acid molecule (e.g., aptamer).SOLUTION: The present disclosure provides a compound having a structure represented by the following formula I. (R independently represents -(CH2) n-, n is an integer of 0-10; R' is independently selected from the group consisting of -H, -OAc, -OBz, -P(NiPr2)(OCH2CH2CN), and -OSiMe2 tBu; R'' is independently selected from the group consisting of hydrogen, 4,4'-dimethoxytrityl (DMT) and triphosphate (-P(O)(OH)-O-P(O)(OH)-O-P(O)(OH)2) or a salt thereof).SELECTED DRAWING: None
【課題】5位修飾シトシン及びそのホスホルアミダイト、ならびにトリホスフェート誘導体、それの製造及び使用方法、及び核酸分子(例えば、アプタマー)の一部としての組成物ならびに修飾ヌクレオシドの使用を提供する。【解決手段】下記式Iに示される構造を含む化合物。(Rは独立して−(CH2)n−であって、nは0〜10の整数であり;R'は−H、−OAc、−OBz、−P(NiPr2)(OCH2CH2CN)、及び−OSiMe2tBuから成る群から独立して選択され;R''は水素、4,4'−ジメトキシトリチル(DMT)及びトリホスフェート(−P(O)(OH)−O−P(O)(OH)−O−P(O)(OH)2)またはそれらの塩から成る群から独立して選択される。)【選択図】なし |
Author | JOHN ROHLOFF NEBOJSA JANJIC BHARAT NATHU GAWANDE |
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DocumentTitleAlternate | シチジン−5−カルボキサミド修飾ヌクレオチド組成物及びそれに関連する方法 |
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SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE |
Title | CYTIDINE-5-CARBOXAMIDE MODIFIED NUCLEOTIDE COMPOSITIONS AND METHODS RELATED THERETO |
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