D-PROLINE DERIVATIVES AS SAP DEPLETING AGENT

• Main Authors: ALEXIS DENIS, JEROME TOUM, OLIVIER MIRGUET
• Format: Patent
• Language: English; Japanese
• Published: 04.03.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide a novel serum amyloid P component (SAP) depleting agent.SOLUTION: The present invention relates to the compound ((2R,2'R)-bis(((tetrahydro-2H-pyran-4-carbonyl)oxy)methyl)1,1'-adipoylbis(pyrrolidine-2-carboxylate), pharmaceutical compositions comprising the same, and the use of the same for treatment of diseases or disorders in which depletion of serum amyloid P component (SAP) is beneficial, including amyloidosis, Alzheimer's disease, type 2 diabetes mellitus and osteoarthritis.SELECTED DRAWING: None 【課題】新規血清アミロイドＰ成分（ＳＡＰ）の枯渇剤の提供。【解決手段】化合物（（２Ｒ，２'Ｒ）−ビス（（（テトラヒドロ−２Ｈ−ピラン−４−カルボニル）オキシ）メチル）１，１'−アジポイルビス（ピロリジン−２−カルボキシレート）、それを含んでなる医薬組成物、ならびにアミロイドーシス、アルツハイマー病、２型糖尿病および骨関節炎を含む、血清アミロイドＰ成分（ＳＡＰ）の枯渇が有益である疾患または障害の処置のためのその使用に関する。【選択図】なし