DEVICES AND METHODS FOR CONTINUOUS DRUG DELIVERY VIA MOUTH
To provide a drug delivery device held in the mouth and continuously administering either a liquid comprising a drug dissolved and/or dispersed in water or in a non-toxic liquid, or a drug in a solid form.SOLUTION: The drug delivery device is configured to be removably inserted in a patient's m...
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Format | Patent |
Language | English Japanese |
Published |
24.12.2020
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Abstract | To provide a drug delivery device held in the mouth and continuously administering either a liquid comprising a drug dissolved and/or dispersed in water or in a non-toxic liquid, or a drug in a solid form.SOLUTION: The drug delivery device is configured to be removably inserted in a patient's mouth for continuous or semi-continuous intraoral administration of a pharmaceutical composition comprising a drug, and comprises: (i) a fastener to removably secure the drug delivery device to a surface of the patient's mouth; (ii) an electrical or mechanical pump; (iii) an oral liquid impermeable drug reservoir having a volume from 0.1 mL to 5 mL and comprising a pharmaceutical composition comprising levodopa or a levodopa prodrug as a suspension or as a solid; and (iv) an automatic stopper/starter.SELECTED DRAWING: None
【課題】口内に保持され、水もしくは非毒性液体中に溶解および/または分散された薬物を含む液体、または固体形態における薬物のいずれかを継続的に投与する、薬物送達デバイスを提供すること。【解決手段】この薬物送達デバイスは、薬物を含む医薬品組成物の連続または半連続口腔内投与のために、患者の口内に着脱可能に挿入されるように構成され、(i)前記薬物送達デバイスを前記患者の口の表面に着脱可能に固着するための締結具と、(ii)電気または機械ポンプと、(iii)0.1mL〜5mLの容積を有し、レボドパまたはレボドパプロドラッグを懸濁液として、または固体として含む医薬品組成物を含む、経口液不浸透性薬物リザーバと、(iv)自動停止/始動装置とを備え得る。【選択図】なし |
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AbstractList | To provide a drug delivery device held in the mouth and continuously administering either a liquid comprising a drug dissolved and/or dispersed in water or in a non-toxic liquid, or a drug in a solid form.SOLUTION: The drug delivery device is configured to be removably inserted in a patient's mouth for continuous or semi-continuous intraoral administration of a pharmaceutical composition comprising a drug, and comprises: (i) a fastener to removably secure the drug delivery device to a surface of the patient's mouth; (ii) an electrical or mechanical pump; (iii) an oral liquid impermeable drug reservoir having a volume from 0.1 mL to 5 mL and comprising a pharmaceutical composition comprising levodopa or a levodopa prodrug as a suspension or as a solid; and (iv) an automatic stopper/starter.SELECTED DRAWING: None
【課題】口内に保持され、水もしくは非毒性液体中に溶解および/または分散された薬物を含む液体、または固体形態における薬物のいずれかを継続的に投与する、薬物送達デバイスを提供すること。【解決手段】この薬物送達デバイスは、薬物を含む医薬品組成物の連続または半連続口腔内投与のために、患者の口内に着脱可能に挿入されるように構成され、(i)前記薬物送達デバイスを前記患者の口の表面に着脱可能に固着するための締結具と、(ii)電気または機械ポンプと、(iii)0.1mL〜5mLの容積を有し、レボドパまたはレボドパプロドラッグを懸濁液として、または固体として含む医薬品組成物を含む、経口液不浸透性薬物リザーバと、(iv)自動停止/始動装置とを備え得る。【選択図】なし |
Author | HELLER ADAM HELLER EPHRAIM BRUCE REHLAENDER JOHN SPIRIDIGLIOZZI |
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DocumentTitleAlternate | 口を介する連続的薬物送達のためのデバイスおよび方法 |
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SubjectTerms | APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE DENTISTRY DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
Title | DEVICES AND METHODS FOR CONTINUOUS DRUG DELIVERY VIA MOUTH |
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