PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF

• Main Authors: SHAH SYED M, JAN SZELIGA, GALEN RADEBAUGH, NIKETA PATEL, ZHANG HUYI, NATALIYA BAZHINA, JOHN LOKHNAUTH, CHRISTIAN OFSLAGER, GEORGE JOSEPH DONATO III, STEVEN R FABIAN, CHARLES MELUCCI, TIANMIN ZHU, SREENIVASULU MEGATI
• Format: Patent
• Language: English; Japanese
• Published: 10.12.2020
• Subjects: CHEMISTRY; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide peripheral opioid receptor antagonists and formulations containing the same.SOLUTION: The present invention provides a compound represented by formula I in the figure, and formulations containing the same. [In the formula, R1 and R2 are each independently a C1-6 aliphatic group; and X- is a suitable anion.]SELECTED DRAWING: None 【課題】末梢オピオイド受容体アンタゴニストおよびそれを含有する製剤の提供。【解決手段】式Ｉ：［式中、Ｒ１およびＲ２は、各々独立して、Ｃ１−６脂肪族であり；Ｘ−は、適当なアニオンである］で示される化合物およびそれを含有する製剤。【選択図】なし