PHARMACEUTICALLY ACTIVE COMPOUNDS

• Main Authors: JASON JOHN SHIERS, COLIN PETER SAMBROOK-SMITH, NAYLOR ALAN, JOSEPH WILLIAM WRIGGLESWORTH, JOHN PAUL WATTS, STUART THOMAS ONIONS, MOHAMMED ABDUL QUDDUS, DEREK LONDESBROUGH
• Format: Patent
• Language: English; Japanese
• Published: 26.11.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; STEROIDS

To provide pyridine, pyridazine and triazine derivatives that are useful in the treatment of cancer.SOLUTION: The invention is directed to compounds of general formula (I), and pharmaceutical compositions containing such compounds. The compounds and compositions have valuable pharmaceutical properties. In particular, they may be used for the treatment of cancer. Novel intermediates and novel methods of preparation are also disclosed.SELECTED DRAWING: Figure 13 【課題】 本発明は、癌治療に有用な、ピリジン、ピリダジン及びトリアジンの誘導体に関する。【解決手段】 本発明は、一般式（Ｉ）の化合物及びこのような化合物を含む医薬組成物に関する。本化合物及び組成物は、有用な医薬的特性を有する。特に、これらは癌治療に使用することができる。新規な中間体及び新規な調製方法も開示される。【化２５３】【選択図】 図１３