METHOD OF TARGETING SPECIFIC CELL POPULATIONS USING CELL-BINDING AGENT MAYTANSINOID CONJUGATES LINKED VIA NON-CLEAVABLE LINKER, THOSE CONJUGATES, AND METHODS OF MAKING THOSE CONJUGATES

• Main Authors: LUTZ ROBERT, XIE HONGSHENG, CHARI RAVI, KOVTUN YELENA, STEEVES RITA
• Format: Patent
• Language: English; Japanese
• Published: 26.11.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide a method for targeting maytansinoids to a selected cell population.SOLUTION: The method comprises contacting a cell population or tissue presumed to contain the selected cell population with a cell-binding agent maytansinoid conjugate, where one or more maytansinoids are covalently linked to the cell-binding agent via a non-cleavable linker (e.g., SMCC represented by the formula (I) in the figure), and the cell-binding agent binds to cells of the selected cell population.SELECTED DRAWING: None 【課題】選択された細胞集団を標的としてメイタンシノイドを向かわせるための方法の提供。【解決手段】選択された細胞集団を含有すると推測される細胞集団または組織を、細胞結合物質メイタンシノイド複合体と接触させることを包含し、その場合１つまたはそれより多くのメイタンシノイドは非開裂リンカー（例えば、下記式（Ｉ）で示されるＳＭＣＣ）を介して細胞結合物質に共有結合で連結され、そして当該細胞結合物質が選択された細胞集団の細胞に結合する方法。【選択図】なし