END CAPPED NUCLEIC ACID MOLECULES

To disclose, regarding nucleic acids that contain modifications at the 5'-end, 3'-end or 5'-end and 3'-ends, compounds that can be used to make the modified nucleic acids, where the modified nucleic acids have improved expression, lower immunogenicity and improved stability compa...

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Main Authors DAVID BARNES-SEEMAN, JOHN LOUIS DIENER, SARAH WILLIAMS, SCOTT LOUIS COHEN, YUAN JUN, CHRISTIAN GAMPE, JAMES ROACHE, FREDERIC ZECRI, AMY WHITE
Format Patent
LanguageEnglish
Japanese
Published 12.11.2020
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Abstract To disclose, regarding nucleic acids that contain modifications at the 5'-end, 3'-end or 5'-end and 3'-ends, compounds that can be used to make the modified nucleic acids, where the modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.SOLUTION: The present invention provides a compound of formula I or a salt thereof.SELECTED DRAWING: None 【課題】５'末端、３'末端、または５'末端および３'末端に改変を含有する核酸に関し、改変核酸を製造するために使用され得る化合物が開示される。改変核酸は、非改変核酸と比較して、発現の改善、より低い免疫原性、および安定性の改善を有する。【解決手段】式Ｉの化合物またはその塩。【選択図】なし
AbstractList To disclose, regarding nucleic acids that contain modifications at the 5'-end, 3'-end or 5'-end and 3'-ends, compounds that can be used to make the modified nucleic acids, where the modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.SOLUTION: The present invention provides a compound of formula I or a salt thereof.SELECTED DRAWING: None 【課題】５'末端、３'末端、または５'末端および３'末端に改変を含有する核酸に関し、改変核酸を製造するために使用され得る化合物が開示される。改変核酸は、非改変核酸と比較して、発現の改善、より低い免疫原性、および安定性の改善を有する。【解決手段】式Ｉの化合物またはその塩。【選択図】なし
Author SCOTT LOUIS COHEN
JOHN LOUIS DIENER
CHRISTIAN GAMPE
DAVID BARNES-SEEMAN
JAMES ROACHE
AMY WHITE
SARAH WILLIAMS
YUAN JUN
FREDERIC ZECRI
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– fullname: YUAN JUN
– fullname: CHRISTIAN GAMPE
– fullname: JAMES ROACHE
– fullname: FREDERIC ZECRI
– fullname: AMY WHITE
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Snippet To disclose, regarding nucleic acids that contain modifications at the 5'-end, 3'-end or 5'-end and 3'-ends, compounds that can be used to make the modified...
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SubjectTerms ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
Title END CAPPED NUCLEIC ACID MOLECULES
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