BIOMARKER FOR USE IN TREATING ANEMIA

To provide a method for treating anemia in a subject in need of treatment.SOLUTION: Provided herein are methods of treating diseases associated with anemia or ineffective erythropoiesis by using the level and/or activity of a ligand of an activin receptor, in particular, growth differentiation facto...

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Bibliographic Details
Main Authors RAJESH CHOPRA, THIAGO TROVATI MACIEL, OLIVIER HERMINE, IVAN CRUZ MOURA, AURELIE FRICOT, VICTORIA SUNG, MICHAEL DUSSIOT
Format Patent
LanguageEnglish
Japanese
Published 12.11.2020
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:To provide a method for treating anemia in a subject in need of treatment.SOLUTION: Provided herein are methods of treating diseases associated with anemia or ineffective erythropoiesis by using the level and/or activity of a ligand of an activin receptor, in particular, growth differentiation factor 11 (GDF11), as an indicator of responsiveness of a patient to the treatment, efficacy of the treatment, or an appropriate dosage for the treatment with an activin type II receptor inhibitor.SELECTED DRAWING: Figure 1A-C 【課題】治療を必要とする対象における貧血を治療する方法を提供する。【解決手段】アクチビン受容体のリガンド、特に、成長分化因子１１（ＧＤＦ１１）のレベル及び/又は活性を、治療に対する患者の応答性、治療の効力、又はアクチビンＩＩ型受容体インヒビターによる治療のための適切な投薬量の指標として使用することにより、貧血又は無効造血と関連する疾患を治療する方法。【選択図】図１Ａ−Ｃ
Bibliography:Application Number: JP20200108569