SMYD INHIBITORS
To provide compounds that are SMYD protein inhibitors, such as SMYD3 and SMYD2 inhibitors, as drugs for treating cancer in a mammal.SOLUTION: For example, the compounds are N-(1-(1-((S)-2-aminopropanoyl)piperidin-4-yl)ethyl)-6-chloro-2-oxoindolin-5-carboxamide, N-(1-(4-aminobutanoyl)piperidin-4-yl)-...
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Language | English Japanese |
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11.06.2020
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Abstract | To provide compounds that are SMYD protein inhibitors, such as SMYD3 and SMYD2 inhibitors, as drugs for treating cancer in a mammal.SOLUTION: For example, the compounds are N-(1-(1-((S)-2-aminopropanoyl)piperidin-4-yl)ethyl)-6-chloro-2-oxoindolin-5-carboxamide, N-(1-(4-aminobutanoyl)piperidin-4-yl)-1H-1,2,4-triazol-5-carboxamide, N-((1r,4r)-4-aminocyclohexyl)-1-benzyl-3-methyl-1H-pyrazol-5-carboxamide hydrochloride, and 2-oxo-N-(piperidin-4-ylmethyl)indolin-5-carboxamide hydrochloride.SELECTED DRAWING: None
【課題】哺乳動物の癌を治療するための薬剤としてのSMYD3およびSMYD2阻害剤などのSMYDタンパク質阻害剤となる化合物の提供。【解決手段】例えば、N−(1−(1−((S)−2−アミノプロパノイル)ピペリジン−4−イル)エチル)−6−クロロ−2−オキソインドリン−5−カルボキサミド、N−(1−(4−アミノブタノイル)ピペリジン−4−イル)−1H−1,2,4−トリアゾール−5−カルボキサミド、N−((1r,4r)−4−アミノシクロヘキシル)−1−ベンジル−3−メチル−1H−ピラゾール−5−カルボキサミド塩酸塩、2−オキソ−N−(ピペリジン−4−イルメチル)インドリン−5−カルボキサミド塩酸塩。【選択図】なし |
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AbstractList | To provide compounds that are SMYD protein inhibitors, such as SMYD3 and SMYD2 inhibitors, as drugs for treating cancer in a mammal.SOLUTION: For example, the compounds are N-(1-(1-((S)-2-aminopropanoyl)piperidin-4-yl)ethyl)-6-chloro-2-oxoindolin-5-carboxamide, N-(1-(4-aminobutanoyl)piperidin-4-yl)-1H-1,2,4-triazol-5-carboxamide, N-((1r,4r)-4-aminocyclohexyl)-1-benzyl-3-methyl-1H-pyrazol-5-carboxamide hydrochloride, and 2-oxo-N-(piperidin-4-ylmethyl)indolin-5-carboxamide hydrochloride.SELECTED DRAWING: None
【課題】哺乳動物の癌を治療するための薬剤としてのSMYD3およびSMYD2阻害剤などのSMYDタンパク質阻害剤となる化合物の提供。【解決手段】例えば、N−(1−(1−((S)−2−アミノプロパノイル)ピペリジン−4−イル)エチル)−6−クロロ−2−オキソインドリン−5−カルボキサミド、N−(1−(4−アミノブタノイル)ピペリジン−4−イル)−1H−1,2,4−トリアゾール−5−カルボキサミド、N−((1r,4r)−4−アミノシクロヘキシル)−1−ベンジル−3−メチル−1H−ピラゾール−5−カルボキサミド塩酸塩、2−オキソ−N−(ピペリジン−4−イルメチル)インドリン−5−カルボキサミド塩酸塩。【選択図】なし |
Author | MICHAEL JOHN MUNCHHOF KEVIN WAYNE KUNTZ JAMES EDWARD JOHN MILLS LORNA HELEN MITCHELL MEGAN ALENE CLOONAN FOLEY DARREN MARTIN HARVEY |
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Snippet | To provide compounds that are SMYD protein inhibitors, such as SMYD3 and SMYD2 inhibitors, as drugs for treating cancer in a mammal.SOLUTION: For example, the... |
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Title | SMYD INHIBITORS |
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