BISPECIFIC ANTI-VEGF/ANTI-ANG-2 ANTIBODIES AND THEIR USE IN TREATMENT OF OCULAR VASCULAR DISEASES

• Main Authors: MATTHIAS RUETH, JOERG THOMAS REGULA, KLEIN CHRISTIAN, HARALD DUERR, FRANK HERTING, STUBENRAUCH KAJ GUNNAR
• Format: Patent
• Language: English; Japanese
• Published: 23.04.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide a method for the reduction of the viscosity of an antibody (including a bispecific antibody) of human IgG1 or human IgG4 subclass.SOLUTION: The present invention relates to a bispecific antibody against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2) of human IgG1 or IgG4 subclass with mutations I253A, H310A, and H435A, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.SELECTED DRAWING: None 【課題】ヒトＩｇＧ１又はヒトＩｇＧ４サブクラスの抗体（二重特異性抗体を含む）の粘度の低下のための方法の提供。【解決手段】変異Ｉ２５３Ａ、Ｈ３１０Ａ、及びＨ４３５Ａを伴うヒトＩｇＧ１又はＩｇＧ４サブクラスのヒト血管内皮成長因子（ＶＥＧＦ／ＶＥＧＦ−Ａ）に対する及びヒトアンギオポエチン２（ＡＮＧ−２）に対する二重特異性抗体、それらを産生するための方法、前記抗体を含む医薬的組成物、ならびにそれらの使用に関する。【選択図】なし