ORALLY DISINTEGRATING TABLETS CONTAINING SUGAR OR SUGAR ALCOHOL GRANULE MODIFIED WITH ETHYL CELLULOSE
To provide orally disintegrating tablets containing as a main excipient sugar or sugar alcohol granule surface-modified by wet granulation with an ethylcellulose solution.SOLUTION: An excellent orally disintegrating tablet can be obtained, which can obtain high hardness even with low-pressure tablet...
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Format | Patent |
Language | English Japanese |
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21.11.2019
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Abstract | To provide orally disintegrating tablets containing as a main excipient sugar or sugar alcohol granule surface-modified by wet granulation with an ethylcellulose solution.SOLUTION: An excellent orally disintegrating tablet can be obtained, which can obtain high hardness even with low-pressure tableting, by applying a main excipient in the form of granules in which sugar or sugar alcohol is surface-modified with an ethylcellulose solution, can be applied to practical production without tableting problems, does not disintegrate in handling during drug production, transportation, storage, packaging, and preparation works, and can suppress hardness reduction and disintegration delay even when storing for long period of time under high humidity conditions.SELECTED DRAWING: Figure 1
【課題】エチルセルロース溶液で湿式造粒して表面改質した糖又は糖アルコール顆粒を主賦形剤として含む口腔崩壊錠を提供する。【解決手段】糖又は糖アルコールをエチルセルロース溶液で表面改質した顆粒形態の主賦形剤を適用することによって、低圧打錠でも高い硬度を得ることができ、打錠障害なく実生産適用が可能であり、薬剤の製造、運搬、保管、分包、調製作業時の取扱中にも崩れず、高湿度条件下に長期間貯蔵しても硬度の低下及び崩壊の遅延を抑制できる優れた口腔崩壊錠を得ることができる。【選択図】図1 |
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AbstractList | To provide orally disintegrating tablets containing as a main excipient sugar or sugar alcohol granule surface-modified by wet granulation with an ethylcellulose solution.SOLUTION: An excellent orally disintegrating tablet can be obtained, which can obtain high hardness even with low-pressure tableting, by applying a main excipient in the form of granules in which sugar or sugar alcohol is surface-modified with an ethylcellulose solution, can be applied to practical production without tableting problems, does not disintegrate in handling during drug production, transportation, storage, packaging, and preparation works, and can suppress hardness reduction and disintegration delay even when storing for long period of time under high humidity conditions.SELECTED DRAWING: Figure 1
【課題】エチルセルロース溶液で湿式造粒して表面改質した糖又は糖アルコール顆粒を主賦形剤として含む口腔崩壊錠を提供する。【解決手段】糖又は糖アルコールをエチルセルロース溶液で表面改質した顆粒形態の主賦形剤を適用することによって、低圧打錠でも高い硬度を得ることができ、打錠障害なく実生産適用が可能であり、薬剤の製造、運搬、保管、分包、調製作業時の取扱中にも崩れず、高湿度条件下に長期間貯蔵しても硬度の低下及び崩壊の遅延を抑制できる優れた口腔崩壊錠を得ることができる。【選択図】図1 |
Author | OH EUN JO CHOI KYU SANG PARK YO JIN KAM SUNG HOON LEE JU YOUNG |
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DocumentTitleAlternate | エチルセルロースで改質された糖又は糖アルコール顆粒を含む口腔崩壊錠 |
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Title | ORALLY DISINTEGRATING TABLETS CONTAINING SUGAR OR SUGAR ALCOHOL GRANULE MODIFIED WITH ETHYL CELLULOSE |
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