PARTICLE, METHOD FOR PRODUCING PARTICLE, AFFINITY PARTICLE, AND INSPECTION REAGENT AND INSPECTION KIT CONTAINING THE SAME, AND METHOD OF DETECTING TARGET MATERIAL

• Main Authors: NAKAHAMA KAZUMICHI, KOBAYASHI MOTOKAZU, YAMAUCHI FUMIO, SUDA SAKAE, KANEZAKI KENGO
• Format: Patent
• Language: English; Japanese
• Published: 31.10.2019
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS; MEASURING; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PHYSICS; TESTING; THEIR PREPARATION OR CHEMICAL WORKING-UP

To provide a particle that has a high ability of inhibiting nonspecific absorption, and having a functional group for chemical bonding of ligand on the particle surface, and a novel method for producing the particle in high yields.SOLUTION: A method for producing a particle includes the steps of preparing an aqueous solution in which a first radical-polymerizable monomer having a carboxyl group is dissolved, and of mixing the aqueous solution with a second radical-polymerizable monomer having an epoxy group and a radical polymerization initiator, and radical polymerizing them, to form a particulate polymer.SELECTED DRAWING: None 【課題】 非特異吸着を抑制する能力が高く、且つ、粒子表面にリガンドを化学結合するための官能基を有する粒子、及び、この粒子を高収率で製造するための新規手法を提供する。【解決手段】 カルボキシル基を有する第１のラジカル重合性単量体を溶解させた水溶液を用意する工程と、前記水溶液と、エポキシ基を有する第２のラジカル重合性単量体と、ラジカル重合開始剤とを混合し、ラジカル重合することによって粒状重合体を形成させる工程を含むことを特徴とする粒子の製造方法。【選択図】 なし