PHARMACEUTICAL FOR TREATING EYE DISEASE, LUNG DISEASE OR ATHEROSCLEROSIS BY REMOVING SENESCENT CELL FROM MORBID TISSUE

• Main Authors: DARREN J BAKER, ALBERT DAVALOS, JENNIFER ELISSEEFF, KIM CHAEKYU, JEON OKHEE, TAMAR TCHKONIA, JAN M A VAN DEURSEN, REMI-MARTIN LABERGE, ZHU YI, JAMES L KIRKLAND, ALAIN PHILIPPE VASSEROT, NATHANIEL DAVID, JUDITH CAMPISI, BENNETT G CHILDS, MARCO DEMARIA
• Format: Patent
• Language: English; Japanese
• Published: 29.08.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

To provide a method for selectively killing senescent cells and treating a senescence-associated disease or disorder, comprising administering a senolytic agent.SOLUTION: The senolytic agent is selected from: an MDM2 inhibitor; an inhibitor of one or more BCL-2 anti-apoptotic protein family members...