TREATING ORAL LESIONS USING PLACENTAL EXTRACELLULAR MATRIX

To provide novel collagen-containing compositions for treatment of oral lesions.SOLUTION: A method for treating an individual having an oral lesion comprises administering to the oral lesion a therapeutically effective amount of extracellular matrix. The extracellular matrix is human placental extra...

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Bibliographic Details
Main Authors ROBERT J HARIRI, WOLFGANG HOFGARTNER, JODI P GURNEY, MOHIT B BHATIA
Format Patent
LanguageEnglish
Japanese
Published 04.07.2019
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide novel collagen-containing compositions for treatment of oral lesions.SOLUTION: A method for treating an individual having an oral lesion comprises administering to the oral lesion a therapeutically effective amount of extracellular matrix. The extracellular matrix is human placental extracellular matrix that has not been chemically modified or contacted with an exogenous protease. The extracellular matrix preferably has been prepared by treatment with a surfactant. The extracellular matrix preferably comprises collagen, and further preferably comprises one or more selected from among laminin, fibronectin, elastin and glycosaminoglycan.SELECTED DRAWING: Figure 1 【課題】口腔病変の治療のためのコラーゲン含有新規組成物の提供。【解決手段】細胞外マトリクスの治療有効量を口腔病変へ投与することを含む、口腔病変を有する個体を治療する方法。前記細胞外マトリクスは、化学修飾されていないか又は外来性プロテアーゼと接触されていないヒト胎盤由来の細胞外マトリクスであって、界面活性剤による処置により調製されたものであることが好ましい。前記細胞外マトリクスは、コラーゲンを含むことが好ましく、ラミニン、フィブロネクチン、エラスチン及びグリコサミノグリカンから選択される１種以上を更に含むことが好ましい。【選択図】図１
Bibliography:Application Number: JP20190016611