NITROXYL DONORS WITH IMPROVED THERAPEUTIC INDEX
To provide compositions containing nitroxyl donating compounds for parenteral and/or oral administration that are sufficiently stable and have favorable pharmacological and toxicological profiles.SOLUTION: The present invention provides N-substituted hydroxylamine derivative compounds, which are nit...
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Main Authors | , , , , |
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Format | Patent |
Language | English Japanese |
Published |
13.06.2019
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Subjects | |
Online Access | Get full text |
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Summary: | To provide compositions containing nitroxyl donating compounds for parenteral and/or oral administration that are sufficiently stable and have favorable pharmacological and toxicological profiles.SOLUTION: The present invention provides N-substituted hydroxylamine derivative compounds, which are nitroxyl donating compounds very useful in treating cardiovascular disease (e.g., cardiac failure) and having a proper toxicological profile, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions.SELECTED DRAWING: None
【課題】非経口および/または経口投与するためにニトロキシル供与性化合物を含有する組成物であって、十分に安定であり、かつ有利な薬理学的および毒性学的プロファイルを有する組成物を提供する。【解決手段】心血管疾患(例えば、心不全)を処置する際に非常に有効であり、適切な毒性学的プロファイルを有しているニトロキシル供与性化合物であるN−置換ヒドロキシルアミン誘導体化合物、当該化合物を含む医薬組成物およびキット、ならびに当該化合物または医薬組成物を使用する方法。【選択図】なし |
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Bibliography: | Application Number: JP20180228317 |