POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE

• Main Authors: JEROMY J COTTELL, JI MINGZHE, PHILIP ANTHONY MORGANELLI, HAOLUN JIN, ELIZABETH M BACON, ZHENHONG R CAI, SCOTT E LAZERWITH, HYUNG-JUNG PYUN
• Format: Patent
• Language: English; Japanese
• Published: 08.11.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide polycyclic-carbamoylpyridone compounds and their pharmaceutical use.SOLUTION: The invention provides compounds for use in treatment of human immunodeficiency virus (HIV) infection. The compounds have the formula (Ia), which includes stereoisomers and pharmaceutically acceptable salts thereof. [In the formula, A' represents Cmonocyclic cycloalkyl or the like; Rrepresents H, Calkyl, or the like; Rrepresents H, Chaloalkyl, or the like; and Rrepresents phenyl substituted with three or more substituents.]SELECTED DRAWING: None 【課題】多環式カルバモイルピリドン化合物およびそれらの薬学的使用の提供。【解決手段】ヒト免疫不全ウイルス（ＨＩＶ）感染の処置において使用するための化合物で、式（Ｉａ）を有し、（Ｉａ）は、その立体異性体および薬学的に許容される塩を含む［式中、Ａ'は、Ｃ３〜７単環式シクロアルキル等、Ｒ１は、Ｈ、Ｃ１〜４アルキル等、Ｒ２は、Ｈ、Ｃ１〜３ハロアルキル等、Ｒ３は、３個以上の置換基で置換されているフェニルを表す］。【選択図】なし