HUMAN MONOCLONAL ANTIBODIES TO EPIDERMAL GROWTH FACTOR RECEPTOR

• Main Authors: JAKOBOVITS AYA, YANG XIAO-DONG, GALLO MICHAEL, JIA XIAOI
• Format: Patent
• Language: English; Japanese
• Published: 17.05.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide human monoclonal antibodies for treatment with antibody therapy of a solid cancer by means of an antibody against human epidermal growth factor receptor (EGF-r).SOLUTION: There are provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r). Also provided are nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences from CDR1 through CDR3. Hybridomas expressing such immunoglobulin molecules and monoclonal antibodies are also provided.SELECTED DRAWING: None 【課題】ヒト上皮細胞増殖因子受容体（EGF-r）に対する抗体によって固形癌を抗体療法により治療するための、ヒトモノクローナル抗体の提供。【解決手段】ヒト上皮細胞増殖因子受容体（EGF-r）に対する完全なヒトモノクローナル抗体が提供される。重鎖および軽鎖免疫グロブリン分子をコードするヌクレオチド配列および該分子を含むアミノ酸配列、特にCDR1からCDR3までの近接する重鎖および軽鎖配列に相当する配列が提供される。そのような免疫グロブリン分子およびモノクローナル抗体を発現するハイブリドーマも提供される。【選択図】なし