METHOD FOR PRODUCING BICYCLIC AMINES

• Main Authors: YANASE MANABU, ODA YASUHIRO
• Format: Patent
• Language: English; Japanese
• Published: 10.05.2018
• Subjects: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

PROBLEM TO BE SOLVED: To provide a method for producing bicyclic amines with improved yield thereof.SOLUTION: Provided is a method for producing bicyclic amine compounds represented by formula (1), which are hydroxyalkyltriethylenediamines, by subjecting a raw material composition to intramolecular dehydration in vapor phase in the presence of a solid catalyst, where a mixture of N-dihydroxypropylpiperazines and N,N'-bis(dihydroxypropyl)piperazines is used as the raw material composition and an inorganic oxide represented by formula (4) is used as the solid catalyst [Rto Rare each independently H, a C1-4 alkyl group, a hydroxy group, a hydroxymethyl group, or a C1-4 alkoxy group]. AlMPO(4) [M is an alkali metal or an alkaline earth metal; P is phosphorus; 0.001≤b/a≤0.5 (molar ratio); 0.01≤c/a≤0.5 (molar ratio); and d is a number which depends on the bonding states of respective atoms].SELECTED DRAWING: None 【課題】二環式アミンの収率が向上した二環式アミンの製造方法の提供。【解決手段】原料組成物を、固体触媒存在下、気相中で分子内脱水させ、式（１）で示される二環式アミン化合物を製造する方法であって、原料組成物として、Ｎ−ジヒドロキシプロピルピペラジン類と、Ｎ，Ｎ'（−ビス（ジヒドロキシプロピル）ピペラジン類の混合物を用い、固体触媒として式（４）で表される無気酸化物を用いる、ヒドロキシアルキルトリエチレンジアミン類である二環式アミン化合物の製造方法。［Ｒ１〜Ｒ８は各々独立Ｈ、Ｃ１〜４のアルキル基、水酸基、ヒドロキシメチル基、又はＣ１〜４のアルコキシ基］ＡｌａＭｂＰｃＯｄ・・・・・（４）［Ｍはアルカリ金属又はアルカリ土類金属；Ｐは燐；０．００１≦ｂ／ａ≦０．５（モル比）；０．０１≦ｃ／ａ≦０．５（モル比）；ｄは各原子の結合状態に依存の整数］【選択図】なし