HUMAN MONOCLONAL ANTIBODY WITH SPECIFICITY FOR DENGUE VIRUS SEROTYPE 1 E PROTEIN AND USES THEREOF
PROBLEM TO BE SOLVED: To provide compositions and methods for the treatment or prevention of dengue virus infection in a vertebrate subject.SOLUTION: Human neutralizing monoclonal antibodies disclosed herein are isolated from EBV immortalized B cells derived from patients who have recovered from den...
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29.03.2018
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Abstract | PROBLEM TO BE SOLVED: To provide compositions and methods for the treatment or prevention of dengue virus infection in a vertebrate subject.SOLUTION: Human neutralizing monoclonal antibodies disclosed herein are isolated from EBV immortalized B cells derived from patients who have recovered from dengue infection, and bind to a dengue virus serotype 1 envelope protein or a fragment thereof. Also provided are methods for administering such antibodies to a vertebrate subject in an amount effective to reduce, eliminate or prevent relapse from infection.SELECTED DRAWING: Figure 1
【課題】脊椎動物対象におけるデングウイルス感染を治療または予防するための組成物および方法を提供する。【解決手段】デング感染から回復した患者に由来するEBV不死化B細胞から単離された、デングウイルス血清型1のエンベロープタンパク質またはその断片に結合する、ヒト中和モノクローナル抗体を開示する。そのような抗体を、感染からの再発を抑制する、排除する、または防止するのに有効な量で脊椎動物対象に投与するための方法を提供する。【選択図】図1 |
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AbstractList | PROBLEM TO BE SOLVED: To provide compositions and methods for the treatment or prevention of dengue virus infection in a vertebrate subject.SOLUTION: Human neutralizing monoclonal antibodies disclosed herein are isolated from EBV immortalized B cells derived from patients who have recovered from dengue infection, and bind to a dengue virus serotype 1 envelope protein or a fragment thereof. Also provided are methods for administering such antibodies to a vertebrate subject in an amount effective to reduce, eliminate or prevent relapse from infection.SELECTED DRAWING: Figure 1
【課題】脊椎動物対象におけるデングウイルス感染を治療または予防するための組成物および方法を提供する。【解決手段】デング感染から回復した患者に由来するEBV不死化B細胞から単離された、デングウイルス血清型1のエンベロープタンパク質またはその断片に結合する、ヒト中和モノクローナル抗体を開示する。そのような抗体を、感染からの再発を抑制する、排除する、または防止するのに有効な量で脊椎動物対象に投与するための方法を提供する。【選択図】図1 |
Author | LOK SHEE MEI NG MAH LEE MARY MACARY PAUL ANTHONY BRENDON JOHN HANSON EN WE TEO PETRA EVELIINA KUKKARO EE PING EVELYN TEOH LIM ANGELINE PEI CHIEW |
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DocumentTitleAlternate | デングウイルス血清型1のEタンパク質に対して特異性を有するヒトモノクローナル抗体およびその使用 |
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Snippet | PROBLEM TO BE SOLVED: To provide compositions and methods for the treatment or prevention of dengue virus infection in a vertebrate subject.SOLUTION: Human... |
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Title | HUMAN MONOCLONAL ANTIBODY WITH SPECIFICITY FOR DENGUE VIRUS SEROTYPE 1 E PROTEIN AND USES THEREOF |
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