CARBAZOLE-CONTAINING SULFONAMIDES AS CRYPTOCHROME MODULATORS

• Main Authors: ROSS BERSOT, PAUL HUMPHRIES
• Format: Patent
• Language: English; Japanese
• Published: 09.11.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

PROBLEM TO BE SOLVED: To provide carbazole-containing sulfonamides as cryptochrome modulators.SOLUTION: The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I, where the variable R, R, R, R, R, R, R, A, B, C, D, E, F, G, H, a, and b are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing's syndrome, and glaucoma.SELECTED DRAWING: None 【課題】クリプトクロム調節薬としてのカルバゾール含有スルホンアミドを提供すること。【解決手段】本明細書における主題は、構造式Ｉ（式中、可変部Ｒ１、Ｒ２、Ｒ３、Ｒ４、Ｒ５、Ｒ６、Ｒ７、Ａ、Ｂ、Ｃ、Ｄ、Ｅ、Ｆ、Ｇ、Ｈ、ａ、およびｂはそれらに応じて説明）のカルバゾール含有スルホンアミド誘導体およびその薬学的に許容され得る塩または水和物に関する。また、Ｃｒｙ媒介性の疾患または障害、例えば、糖尿病、肥満、メタボリックシンドローム、クッシング症候群、および緑内障を処置するための式Ｉの化合物を含む医薬組成物も提供する。【選択図】なし