PYRROLO [2,3-D]PYRIMIDINE DERIVATIVES AS INHIBITORS OF JANUS- RELATED KINASES (JAK)

• Main Authors: JOSEPH WALTER STROHBACH, RUTH E TENBRINK, NEELU KAILA, JOHN DAVID TRZUPEK, MIHIR D PARIKH, RAYOMAND JAL UNWALLA, TIMOTHY ALLAN JOHNSON, MARK J MITTON-FRY, MATTHEW FRANK BROWN, ASHLEY EDWARD FENWICK, MARK EDWARD FLANAGAN, ANDREA GONZALES, MICHAEL L VAZQUEZ
• Format: Patent
• Language: English; Japanese
• Published: 21.09.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide new compounds that effectively and selectively inhibit specific Janus Kinase (JAK) enzymes, and JAK1 in particular, vs. JAK2.SOLUTION: The present invention provides pyrrolo{2,3-d}pyrimidine derivatives of formula I, or pharmaceutically acceptable salts thereof. The present invention also provides their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them. The present invention also provides animal pharmaceutical compositions containing agonists selected from agonists for modulating mammal immune systems and antiinflammatory agents.SELECTED DRAWING: None 【課題】特異的ヤヌスキナーゼ（ＪＡＫ）酵素、及びＪＡＫ１を特にＪＡＫ２に対して有効にかつ選択的に阻害する新たな化合物の提供。【解決手段】式（Ｉ）で表されるピロロ｛２，３−ｄ｝ピリミジン誘導体又は薬学的に許容できるその塩。ヤヌスキナーゼ（ＪＡＫ）阻害剤としてのそれらの使用、及びそれらを含有する医薬組成物。哺乳類の免疫系をモジュレートする作用物質及び抗炎症剤から選択される作用物質とを含む動物用医薬組成物。【選択図】なし