4-ARYLIMIDAZOLE DERIVATIVE
PROBLEM TO BE SOLVED: To provide a novel compound having strong regulating actions of α7 nicotinic acetylcholine receptor and useful as a therapeutic agent for diseases related to central nervous and/or peripheral nervous cholinergic activity, diseases related to smooth muscular contraction, endocri...
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Format | Patent |
Language | English Japanese |
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08.06.2017
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Abstract | PROBLEM TO BE SOLVED: To provide a novel compound having strong regulating actions of α7 nicotinic acetylcholine receptor and useful as a therapeutic agent for diseases related to central nervous and/or peripheral nervous cholinergic activity, diseases related to smooth muscular contraction, endocrine diseases, neurodegeneration or the like and a pharmaceutical composition containing the compound.SOLUTION: There are provided a compound of the formula (I) and a pharmaceutical composition containing the compound. (I), where X-Y-Z represents N-CO-NRRor the like, Rrepresents a phenyl or the like, Rrepresents chlorine or the like, Rrepresents a hydrogen atom or the like, R, R, Rand Rrepresent a hydrogen atom or the like, Rand Rrepresent Ccycloalkyl or the like and n represents 1 or 2.SELECTED DRAWING: None
【課題】強いα7ニコチン性アセチルコリン受容体の調節作用を有し、中枢神経系及び/又は末梢神経系のコリン作動性に関する疾患、平滑筋収縮に関する疾患、内分泌疾患、神経変性等の治療薬として有用な新規化合物、及び該化合物を含有する医薬組成物の提供。【解決手段】式(I)の化合物、及び該化合物を含有する医薬組成物。[式中、X−Y−Zは、N−CO−NR4AR4B等、R1は、フェニル等、R2Aは塩素等、R2Bは水素原子等、R3A、R3B、R3C及びR3Dは、水素原子等、R4A及びR4Bは、C3−10シクロアルキル等、nは、1又は2を表す。]【選択図】なし |
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AbstractList | PROBLEM TO BE SOLVED: To provide a novel compound having strong regulating actions of α7 nicotinic acetylcholine receptor and useful as a therapeutic agent for diseases related to central nervous and/or peripheral nervous cholinergic activity, diseases related to smooth muscular contraction, endocrine diseases, neurodegeneration or the like and a pharmaceutical composition containing the compound.SOLUTION: There are provided a compound of the formula (I) and a pharmaceutical composition containing the compound. (I), where X-Y-Z represents N-CO-NRRor the like, Rrepresents a phenyl or the like, Rrepresents chlorine or the like, Rrepresents a hydrogen atom or the like, R, R, Rand Rrepresent a hydrogen atom or the like, Rand Rrepresent Ccycloalkyl or the like and n represents 1 or 2.SELECTED DRAWING: None
【課題】強いα7ニコチン性アセチルコリン受容体の調節作用を有し、中枢神経系及び/又は末梢神経系のコリン作動性に関する疾患、平滑筋収縮に関する疾患、内分泌疾患、神経変性等の治療薬として有用な新規化合物、及び該化合物を含有する医薬組成物の提供。【解決手段】式(I)の化合物、及び該化合物を含有する医薬組成物。[式中、X−Y−Zは、N−CO−NR4AR4B等、R1は、フェニル等、R2Aは塩素等、R2Bは水素原子等、R3A、R3B、R3C及びR3Dは、水素原子等、R4A及びR4Bは、C3−10シクロアルキル等、nは、1又は2を表す。]【選択図】なし |
Author | IWATA MITSUTAKA IWATA MASAKADO KAWASUMI MUNEO SUZUKI KUNIKO |
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Snippet | PROBLEM TO BE SOLVED: To provide a novel compound having strong regulating actions of α7 nicotinic acetylcholine receptor and useful as a therapeutic agent for... |
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Title | 4-ARYLIMIDAZOLE DERIVATIVE |
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