4-ARYLIMIDAZOLE DERIVATIVE

• Main Authors: KAWASUMI MUNEO, SUZUKI KUNIKO, IWATA MITSUTAKA, IWATA MASAKADO
• Format: Patent
• Language: English; Japanese
• Published: 08.06.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide a novel compound having strong regulating actions of α7 nicotinic acetylcholine receptor and useful as a therapeutic agent for diseases related to central nervous and/or peripheral nervous cholinergic activity, diseases related to smooth muscular contraction, endocrine diseases, neurodegeneration or the like and a pharmaceutical composition containing the compound.SOLUTION: There are provided a compound of the formula (I) and a pharmaceutical composition containing the compound. (I), where X-Y-Z represents N-CO-NRRor the like, Rrepresents a phenyl or the like, Rrepresents chlorine or the like, Rrepresents a hydrogen atom or the like, R, R, Rand Rrepresent a hydrogen atom or the like, Rand Rrepresent Ccycloalkyl or the like and n represents 1 or 2.SELECTED DRAWING: None 【課題】強いα７ニコチン性アセチルコリン受容体の調節作用を有し、中枢神経系及び／又は末梢神経系のコリン作動性に関する疾患、平滑筋収縮に関する疾患、内分泌疾患、神経変性等の治療薬として有用な新規化合物、及び該化合物を含有する医薬組成物の提供。【解決手段】式（Ｉ）の化合物、及び該化合物を含有する医薬組成物。［式中、Ｘ−Ｙ−Ｚは、Ｎ−ＣＯ−ＮＲ４ＡＲ４Ｂ等、Ｒ１は、フェニル等、Ｒ２Ａは塩素等、Ｒ２Ｂは水素原子等、Ｒ３Ａ、Ｒ３Ｂ、Ｒ３Ｃ及びＲ３Ｄは、水素原子等、Ｒ４Ａ及びＲ４Ｂは、Ｃ３−１０シクロアルキル等、ｎは、１又は２を表す。］【選択図】なし