2'-FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT

• Main Authors: XU JIE, CHO AESOP, ADRIAN S RAY, SAMUEL E METOBO, KIM CHOUNG U
• Format: Patent
• Language: English; Japanese
• Published: 20.04.2017
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; DERIVATIVES THEREOF; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

PROBLEM TO BE SOLVED: To provide a medicine for the treatment of Flaviviridae virus infections, particularly hepatitis C infections caused by both wild type and mutant strains of HCV.SOLUTION: The present invention provides compounds, compositions, and methods wherein triazinyl nucleosides represented by formula (I), nucleoside phosphates and prodrugs thereof, wherein the 2' position of the nucleoside sugar is substituted with halogen and carbon substituents.SELECTED DRAWING: None 【課題】フラビウイルス科ウイルス感染、特にＨＣＶの野生型および変異株の両方によって引き起こされるＣ型肝炎感染の治療のための医薬の提供。【解決手段】式（Ｉ）で表わされるトリアジニルヌクレオシド、ヌクレオシドリン酸塩、及びそのプロドラッグが提供され、そのヌクレオシド糖の２′位置は、ハロゲン及び炭素置換基で置換された化合物、組成物、および方法。【選択図】なし