PYRAZOLO [1, 5A] PYRIMIDINE AND THIENO [3, 2B] PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS

• Main Authors: MATTHEW C LUCAS, ZHAI YAN-SHENG, TALAMAS FRANCISCO XAVIER, JUTTA WANNER, JOHANNES CORNELIUS HERMANN, CHEN SHAOQING, SHARADA SHENVI LABADIE, LIN CLARA JEOU JEN, EVA PAPP, NIDHI ARORA, ANDREAS KUGLSTATTER, AMY GERALDINE MOORE
• Format: Patent
• Language: English; Japanese
• Published: 28.12.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide compounds useful for treatment of autoimmune and inflammatory diseases associated with Interleukin-1 Receptor Associated Kinase.SOLUTION: The present invention provides compounds of the formula I or II, wherein X is N or CH; m is 1 or 2; Ar is optionally substituted aryl or heteroaryl; R1 is H, C1-6 alkyl, alkyl-amino, aminocarbonyl, halo or the like; and R2 is H or C1-6 alkyl.SELECTED DRAWING: None 【課題】インターロイキン−１受容体関連キナーゼに関連した自己免疫及び炎症性疾患の治療に有用な化合物の提供。【解決手段】式Ｉ又はＩＩで表される化合物。［式中、ＸはＮ又はＣＨ；ｍは１又は２；Ａｒは置換されていてもよいアリール又はヘテロアリール；Ｒ１はＨ、Ｃ１−６アルキル、アルキル−アミノ、アミノカルボニル、ハロ等；Ｒ２は水素又はＣ１−６アルキルである］【選択図】なし