MULTIPLE-VARIABLE DOSE REGIMEN FOR TREATING TNFα-RELATED DISORDERS

• Main Authors: TAYLOR LORI K, HOFFMAN REBECCA S, YAN PHILIP, CHARTASH ELLIOT, GRANNEMAN GEORGE RICHARD
• Format: Patent
• Language: English; Japanese
• Published: 01.09.2016
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide a multiple-variable dose method of a TNFα inhibitor for treating a disorder in which TNFα activity is detrimental.SOLUTION: A multiple-variable dose method for treating a disorder in which TNFα activity is detrimental comprises: administering to a subject in need thereof at least one induction dose of a TNFα inhibitor such that a threshold level of the TNFα inhibitor is achieved within an induction phase; and subsequently administering to the subject at least one treatment dose of the TNFα inhibitor within a treatment phase.SELECTED DRAWING: None 【課題】ＴＮＦα活性が有害である障害の治療のためのＴＮＦα阻害剤の複数可変投与方法の提供。【解決手段】ＴＮＦα阻害剤のしきい値レベルが誘導期内に得られるようにＴＮＦα阻害剤の少なくとも１回の誘導投与量をそれを必要とする対象に投与すること，及び，続いて，ＴＮＦα阻害剤の少なくとも１回の治療投与量を治療期内に前記対象に投与することを含む、ＴＮＦα活性が有害である障害を治療する複数可変投与方法。【選択図】なし