MODULATOR OF CELL ADHESION

PROBLEM TO BE SOLVED: To provide a modulator of cell adhesion.SOLUTION: There are provided a compound represented by the formula (I), where Rto R, n, p, A, B, D, E, L and ARgenerally in this application and variations as a class and a sub-class are described, and a pharmaceutically acceptable deriva...

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Bibliographic Details
Main Authors SHEN WANG, ZHONG MIN, BARR KENNETH, JOHAN D OSLOB
Format Patent
LanguageEnglish
Japanese
Published 18.08.2016
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide a modulator of cell adhesion.SOLUTION: There are provided a compound represented by the formula (I), where Rto R, n, p, A, B, D, E, L and ARgenerally in this application and variations as a class and a sub-class are described, and a pharmaceutically acceptable derivative and further a the pharmaceutically acceptable composition and a method of use for treatment of disorders involved by CD11/CD18 of cell adhesion molecule (for example LFA-1). In further other aspect, the invention provides a method of treating disorders involved by CD11/CD18 of cell adhesion molecule including a process of administering a therapeutically effective amount of the compound to subjects who need it.SELECTED DRAWING: None 【課題】 細胞接着のモジュレーターを提供すること【解決手段】 本発明は、式（Ｉ）（式中、Ｒ１−Ｒ４、ｎ、ｐ、Ａ、Ｂ、Ｄ、Ｅ、ＬおよびＡＲ１は、本明細書で一般的に、およびクラスおよびサブクラスでの変形が記載される）で表される化合物およびその薬学的に受容可能な誘導体を提供し、さらに、その薬学的組成物、およびそれを細胞接着分子の（たとえばＬＦＡ−１）のＣＤ１１／ＣＤ１８ファミリーが介在する障害の治療のために使用する方法も提供する。さらに他の態様では、本発明は、細胞接着分子のＣＤ１１／ＣＤ１８ファミリーを介して介在する任意の障害を治療する方法であって、本発明の化合物を、これを必要とする被験体に治療的有効量投与する工程を包含する、方法を提供する。【選択図】なし
Bibliography:Application Number: JP20160100392