ANTI NOTCH-1 ANTIBODIES

• Main Authors: KANG LI, PENG QINGHAI, DANNA MARIE STONE, WEI PING, JOHN ANDREW LIPPINCOTT, ZDENEK HOSTOMSKY
• Format: Patent
• Language: English; Japanese
• Published: 07.07.2016
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide therapeutic agents that regulate the notch-1 signaling pathway for the use of treating cancer.SOLUTION: This invention is directed toward monoclonal antibodies that bind specifically to Notch1. The antibodies bind to at least two epitopes, wherein one epitope resides with the LinA domain of the Notch1 negative regulatory region (NRR), and the other epitope resides within the HD-C domain of the Notch1 NRR.SELECTED DRAWING: Figure 1 【課題】癌の処置に使用するための、ｎｏｔｃｈ−１シグナル伝達経路を調節する治療剤の提供。【解決手段】Ｎｏｔｃｈ１と特異的に結合するモノクローナル抗体であって、少なくとも２種類のエピトープと結合し、一方はＮｏｔｃｈ１負の調節領域（ＮＲＲ）のＬｉｎＡドメイン内にあり、他方はエピトープはＮｏｔｃｈ１ＮＲＲのＨＤ−Ｃドメイン内にある抗体。【選択図】図１