CARBOXYVINYL POLYMER-CONTAINING NANOPARTICLE SUSPENSIONS

PROBLEM TO BE SOLVED: To provide carboxyvinyl polymer-containing nanoparticle suspensions.SOLUTION: The present invention generally relates to suspension compositions having a carboxyvinyl polymer such as a carbomer, a galactomannan such as guar, and a borate compound. A sparingly soluble particulat...

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Bibliographic Details
Main Authors CHOWHAN MASOOD A, MALAY GHOSH, ASGHARIAN BAHRAM, WESLEY WESHIN HAN
Format Patent
LanguageEnglish
Japanese
Published 16.06.2016
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide carboxyvinyl polymer-containing nanoparticle suspensions.SOLUTION: The present invention generally relates to suspension compositions having a carboxyvinyl polymer such as a carbomer, a galactomannan such as guar, and a borate compound. A sparingly soluble particulate compound such as nepafenac is also included in the compositions. The sparingly soluble particulate compound has a small particle size to enhance bioavailability of the compound. A preferred composition of the present invention is a nepafenac suspension comprising a carboxyvinyl polymer of acrylic acid cross-linked with allyl sucrose or allylpentaerythritol, guar, and boric acid.SELECTED DRAWING: Figure 1 【課題】カルボキシビニルポリマー含有ナノ粒子懸濁物の提供。【解決手段】本発明は、一般に、カルボマーなどのカルボキシビニルポリマー、ガーなどのガラクトマンナン、およびボレート化合物を含有する、懸濁組成物に関する。ネパフェナクなどのわずかに可溶性の粒子化合物もまた、この組成物に含有される。このわずかに可溶性の粒子化合物は、この化合物のバイオアベイラビリティを増強するために、小さい粒径を有する。本発明の好ましい組成物は、アリルスクロースまたはアリルペンタエリトリトールと架橋したアクリル酸のカルボキシビニルポリマー、ガー、およびホウ酸を含有する、ネパフェナク懸濁物である。【選択図】図１
Bibliography:Application Number: JP20160056630