REDUCTION OF FLAKE-LIKE AGGREGATION IN NANOPARTICULATE ACTIVE AGENT COMPOSITIONS

PROBLEM TO BE SOLVED: To provide a method of reducing flake-like aggregation in nanoparticulate active agent compositions, and compositions obtained by the method.SOLUTION: The invention provides compositions comprising a nanoparticulate active agent, at least one surface stabilizer and a flake-like...

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Bibliographic Details
Main Authors LIU WEI, RYDE NIELS P, DAVID M SLIFER, PETER SNYDER
Format Patent
LanguageEnglish
Japanese
Published 14.04.2016
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:PROBLEM TO BE SOLVED: To provide a method of reducing flake-like aggregation in nanoparticulate active agent compositions, and compositions obtained by the method.SOLUTION: The invention provides compositions comprising a nanoparticulate active agent, at least one surface stabilizer and a flake-like aggregation reducing agent. The nanoparticulate active agent compositions comprise particles of the active agent having an effective average particle size of less than about 2000 nm. The active agent is applied to various drugs, but preferably is meloxicam.SELECTED DRAWING: None 【課題】ナノ粒子活性物質組成物におけるフレーク状凝集の軽減方法及びその方法によって得られる組成物の提供。【解決手段】ナノ粒子活性物質、少なくとも1つの表面安定剤及びフレーク状凝集軽減剤を含む組成物。該ナノ粒子活性物質組成物は、約2000nm未満の有効平均粒径を有する活性物質の粒子を含む組成物。前記活性物質が種々の薬物に適用されるが、好ましくはメロキシカムである組成物。【選択図】なし
Bibliography:Application Number: JP20150185009