METHOD OF CONVERTING PRIMARY AMIDO-ALCOHOL INTO AMIDE CARBOXYLIC ACID IN HIGH YIELD BY USING WATER AS SOLVENT

• Main Authors: JOSE GUILLERMO ROSA, BIJAN HARICHIAN, CHEN HANG
• Format: Patent
• Language: English; Japanese
• Published: 15.10.2015
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

PROBLEM TO BE SOLVED: To provide an improved method of oxidizing a primary amido-alcohol into a corresponding amido-carboxylic acid in a high yield.SOLUTION: A method comprises reacting an amido-alcohol of formula (1) with an oxidant in the presence of a hindered nitroxide radical and, if necessary,...