CONJUGATES FOR PREVENTION OR TREATMENT OF NICOTINE ADDICTION

• Main Authors: JARI ILMARI FINNEMAN, PARAG ASHOK KOLHE, DAVID CAMERON PRIDE, MICHAEL JOHN MCCLUSKIE, JAMES RICHARD MERSON, DAVIS HEATHER LYNN, DAVID ROBERT STEAD, ERIN KRISTEN PARSONS, BROWN ALAN DANIEL, JENNIFER MARIE THORN, NICKOLAS ANASTASIOU, DAVID P GERVAIS, LIN HOWARD JONES, PAUL ROBERT MEHELIC, KESHAB BHATTACHARYA
• Format: Patent
• Language: English; Japanese
• Published: 20.08.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide nicotine-derived haptens, nicotine-derived hapten-carrier conjugates, and vaccine compositions containing the conjugates, which are useful for enhancing smoking quit rates or reducing smoking relapse rates in smoking cessation therapy and for prevention or treatment of nicotine addiction.SOLUTION: The present invention relates to nicotine-derived hapten-carrier conjugates represented by the formula (III). [W is -CH- or -O-; -(spacer)- is a C-Calkylene group, a C-Calkylene group interrupted by 1 to 4 oxygen atoms and optionally interrupted by a -N(H)C(O)-, or the like; Xis -NH- or the like; m is 0 or 1; n is an integer from 1 to 1000; and Y is a carrier protein such as bacterial toxoids.] 【課題】禁煙治療における断煙率の向上、喫煙再発率の低減、及びニコチン中毒の予防又は治療に有用なニコチン誘導ハプテン、ニコチン誘導ハプテン−担体コンジュゲート、及び前記コンジュゲートを含有するワクチン組成物の提供。【解決手段】式（ＩＩＩ）で表されるニコチン誘導ハプテン−担体コンジュゲート。［Ｗは−ＣＨ２−又は−Ｏ−；−（スペーサー）−はＣ１〜Ｃ８アルキレン基、或いは１〜４個の酸素原子によって中断されており、−Ｎ（Ｈ）Ｃ（Ｏ）−によって中断されていてもよいＣ１〜Ｃ１２アルキレン基等；Ｘ＊は−ＮＨ−等；ｍは０又は１；ｎは１〜１０００の整数；Ｙは細菌トキソイド等の担体タンパク質］【選択図】なし