HETEROCYCLIC CONDENSED IMIDAZOLE DERIVATIVES HAVING AMPK ACTIVATION ACTION

• Main Authors: FUJIOKA MASAHIKO, KOJIMA EIICHI, TANAKA NOBUYUKI, TONOGAKI KEISUKE, KATO MANABU, INO AKIRA, IWATSU MASAFUMI
• Format: Patent
• Language: English; Japanese
• Published: 22.01.2015
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide pharmaceutical compositions having an action to activate adenosine monophosphate-activating protein kinase for treating diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and/or hypertension.SOLUTION: Provided is a composition comprising an imidazo[4,5-a] pyridine compound of the formula in which A is a pyridine ring; Ris independently halogen, hydroxyl, cyano, nitro, carboxy, substituted or unsubstituted alkyl, or substituted or unsubstituted alkenyl; m is an integer of 0-3; Ris hydrogen, or substituted or unsubstituted alkyl; X is -O-; Y is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl or substituted or unsubstituted heterocyclyl. 【課題】アデノシン一リン酸活性化プロテインキナーゼ活性化作用を有する糖尿病、高血糖症、メタボリックシンドローム、肥満、高コレステロール血症及び／又は高血圧治療用医薬組成物の提供。【解決手段】下式で表されるイミダゾ［４，５−ａ］ピリジン化合物を含有する組成物。［Ａ部はピリジン環；Ｒ１は各々独立にハロゲン、ヒドロキシ、シアノ、ニトロ、カルボキシ、置換若しくは非置換のアルキル、置換若しくは非置換のアルケニル等；ｍは０〜３の整数；Ｒ２は水素又は置換若しくは非置換のアルキル；Ｘは−Ｏ−；Ｙは置換若しくは非置換のアリール、置換若しくは非置換のヘテロアリール、置換若しくは非置換のシクロアルキル、置換若しくは非置換のシクロアルケニル又は置換若しくは非置換のヘテロサイクリル）【選択図】なし