PROCESSES FOR CONVERGENT SYNTHESIS OF CALICHEAMICIN DERIVATIVE

PROBLEM TO BE SOLVED: To provide a method of fewer steps involving the calicheamicin moiety with increased yields.SOLUTION: This invention describes processes for convergent synthesis of calicheamicin derivatives expressed by formula (I), and similar analogs using bifunctional and trifunctional link...

Full description

Saved in:
Bibliographic Details
Main Authors GU JIANXIN, MORAN JUSTIN KEITH
Format Patent
LanguageEnglish
Japanese
Published 16.10.2014
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
Online AccessGet full text

Cover

More Information
Summary:PROBLEM TO BE SOLVED: To provide a method of fewer steps involving the calicheamicin moiety with increased yields.SOLUTION: This invention describes processes for convergent synthesis of calicheamicin derivatives expressed by formula (I), and similar analogs using bifunctional and trifunctional linker intermediates. This invention describes the processes for the convergent synthesis of the calicheamicin derivatives, and similar analogs using the bifunctional and trifunctional linker intermediates. The claimed process provides a method of fewer steps involving the calicheamicin moiety with increased yields. 【課題】増加した収率を有するカリケアマイシン部分を含む、より少ないステップの方法を提供すること。【解決手段】本発明は、二官能性および三官能性リンカー中間体を使用する、式（Ｉ）のカリケアマイシン誘導体および同様の類似体のコンバージェント合成方法を記載する。本発明は、二官能性および三官能性リンカー中間体を使用する、カリケアマイシン誘導体および同様の類似体のコンバージェント合成方法を記載する。請求されている方法は、増加した収率を有するカリケアマイシン部分を含む、より少ないステップの方法を提供する。【選択図】なし
Bibliography:Application Number: JP20140144737