GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA

• Main Authors: YAN HAI, ZHANG XIAOSONG, KUAN CHIEN-TSUN, PHILIPP ANGENENDT, KINZLER KENNETH W, RACHEL KARCHIN, SIAN JONES, DARELL BIGNER, BERT VOGELSTEIN, D WILLIAMS PARSONS, REBECCA J LEARY, RIGGINS GREGORY J, VICTOR VELCULESCU, NICKOLAS PAPADOPOULOS, LIN JIMMY CHANG-HO, GIOVANNI PARMIGIANI
• Format: Patent
• Language: English
• Published: 19.06.2014
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a method of characterizing a glioblastoma multiforme (GBM) tumor in a human subject.SOLUTION: Mutations of the R132 residue of isocitrate dehydrogenase (IDH)1 are found in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastoma...