5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS

PROBLEM TO BE SOLVED: To provide compounds which inhibit specific combinations of kinases or target kinase pathways.SOLUTION: The present invention relates to 5-substituted indazole compounds represented by the specified general formula (I) or pharmaceutically acceptable salts of the compounds. The...

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Main Authors ALAN F GASIECKI, BAKKER MARGARETHA, NICOLE TEUSCH, LI BIQIN, MACK HELMUT, PATEL JYOTI R, ANIL VASUDEVAN, DAWN GEORGE, KALVIN DOUGLAS M, GRACIAS VIJAYA J, WAKEFIELD BRIAN D, SARRIS KATHY, NIGEL ST JOHN MOORE, ADRIAN HOBSON, WANG LU, ERIC F JOHNSON, IRINI AKRITOPOULOU-ZANZE, SHUAI QI, MICHMERHUIZEN MELISSA J, ANDREW J LONG, SEAN C TURNER, KOVAR PETER J, KRISTINE FRANK, STEVAN W DJURIC
Format Patent
LanguageEnglish
Published 24.04.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract PROBLEM TO BE SOLVED: To provide compounds which inhibit specific combinations of kinases or target kinase pathways.SOLUTION: The present invention relates to 5-substituted indazole compounds represented by the specified general formula (I) or pharmaceutically acceptable salts of the compounds. The present invention relates also to methods of making the compounds, and to compositions containing the compounds useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim1 and nek2.
AbstractList PROBLEM TO BE SOLVED: To provide compounds which inhibit specific combinations of kinases or target kinase pathways.SOLUTION: The present invention relates to 5-substituted indazole compounds represented by the specified general formula (I) or pharmaceutically acceptable salts of the compounds. The present invention relates also to methods of making the compounds, and to compositions containing the compounds useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim1 and nek2.
Author WAKEFIELD BRIAN D
MACK HELMUT
NIGEL ST JOHN MOORE
KOVAR PETER J
DAWN GEORGE
IRINI AKRITOPOULOU-ZANZE
KRISTINE FRANK
ADRIAN HOBSON
GRACIAS VIJAYA J
BAKKER MARGARETHA
ANDREW J LONG
SHUAI QI
WANG LU
LI BIQIN
ANIL VASUDEVAN
SEAN C TURNER
ALAN F GASIECKI
SARRIS KATHY
KALVIN DOUGLAS M
PATEL JYOTI R
ERIC F JOHNSON
NICOLE TEUSCH
MICHMERHUIZEN MELISSA J
STEVAN W DJURIC
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– fullname: KRISTINE FRANK
– fullname: STEVAN W DJURIC
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Snippet PROBLEM TO BE SOLVED: To provide compounds which inhibit specific combinations of kinases or target kinase pathways.SOLUTION: The present invention relates to...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS
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