PEPTIDE FOR CANCER IMMUNOTHERAPY AND ITS USE

• Main Authors: MASAKI SAGAE, KAWAMURA MARIE, KAWASHIMA HIDENORI
• Format: Patent
• Language: English
• Published: 17.04.2014
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMBINATORIAL CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To discover a peptide useful for immunotherapy of kidney cancer, thereby providing an effective therapy and a method for early diagnosis.SOLUTION: There is provided a peptide characterized in comprising an amino acid sequence of (1) or (2), and having an immune induction activity: ILCEAHCLKV-(1), VIEGDVVSAL-(2). The peptide is a protein capable of activating cytotoxic T cells recognizing kidney cancer antigen protein, and it is characterized in activating helper T cells, cytotoxic T cells, or antigen-presenting cells or dendritic cells pulsed in vitro, or an immune cell population comprising said cells by an in vitro stimulus.