METHOD FOR SCREENING CALCIUM PUMP CONTROLLING SUBSTANCE, METHOD FOR SCREENING INHIBITOR OF MELANIN PIGMENT SYNTHESIS, VECTOR AND CELL

• Main Authors: NAGATA KAZUHIRO, SHIODA AKIRA
• Format: Patent
• Language: English
• Published: 24.02.2014
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a series of technology relevant to calcium transportation mediated by SERCA2.SOLUTION: Provided is a method for screening a substance that controls the calcium pump function of SERCA2, where the screening is carried out by using the ability of the test substance to increase or decrease the expression level or the reduction activity of ERdj5 as an index. Also provided is a screening method for inhibitors of melanin pigment synthesis where the screening is carried out by using the above screening method for SERCA2 calcium pump controlling agent. Also provided are vectors and cells suitable for the screening method.