SALT FORMS OF ATORVASTATIN

PROBLEM TO BE SOLVED: To provide basic salts of atorvastatin that are pure, have good stability, and have advantageous formulation properties compared to conventional salt forms of atorvastatin.SOLUTION: The present invention provides novel salt forms of atorvastatin including salts with ammonium, b...

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Bibliographic Details
Main Authors CAMPETA ANTHONY MICHAEL, LEONARD JASON A, KRZYZANIAK JOSEPH F
Format Patent
LanguageEnglish
Published 13.02.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide basic salts of atorvastatin that are pure, have good stability, and have advantageous formulation properties compared to conventional salt forms of atorvastatin.SOLUTION: The present invention provides novel salt forms of atorvastatin including salts with ammonium, benethamine, benzathine, dibenzylamine, diethylamine, L-lysine, morpholine, olamine, piperazine, and 2-amino-2-methylpropan-1-ol which have desirable properties. The present invention also provides novel crystalline forms of atorvastatin which include salts with erbumine and sodium which have desirable properties.
Bibliography:Application Number: JP20130210068