PURIFICATION AND STABILIZATION OF PEPTIDE AND PROTEIN PHARMACEUTICAL AGENTS

PROBLEM TO BE SOLVED: To provide method for purifying peptides or proteins by incorporating the peptide or protein by facilitating removal one or more impurities, i.e. undesirable components, from the peptide, or protein.SOLUTION: In a preferred embodiment, a peptide, such as insulin, containing one...

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Bibliographic Details
Main Authors WOODS RODNEY J, STEINER SOLOMON S, SULNER JOSEPH W
Format Patent
LanguageEnglish
Published 14.03.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide method for purifying peptides or proteins by incorporating the peptide or protein by facilitating removal one or more impurities, i.e. undesirable components, from the peptide, or protein.SOLUTION: In a preferred embodiment, a peptide, such as insulin, containing one or more impurities, e.g., zinc ions, is entrapped in diketopiperazine to form a precipitate of peptide/diketopiperazine/impurity, which is then washed with a solvent for the impurity to be removed, which is a nonsolvent for the diketopiperazine and a nonsolvent for the peptide.
Bibliography:Application Number: JP20120230348