REGULATION OF VIRAL GENE EXPRESSION

• Main Authors: DE HAAN PETRUS THEODORUS, HEIFETZ PETER BERNARD, PATTON DAVID ANDREW, GIELEN JOHANNES JACOBUS LUDGERUS, LEVIN JOSHUA ZVI, QUE QIUDENG
• Format: Patent
• Language: English
• Published: 22.04.2010
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TRAPPING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To develop a method to alter the expression of a viral gene in a cell using sense and antisense RNA fragments of the gene. SOLUTION: The methods use sense and antisense RNA fragments of the gene. The sense and antisense RNA fragments are capable of pairing and forming a double-stranded RNA molecule, thereby altering the expression of the gene. The present invention also includes cells, plants or animals, their progeny and seeds derived thereof, obtained using the method. Preferably, the expression of the gene provides such cells, plants or animals resistant or tolerant to viruses. COPYRIGHT: (C)2010,JPO&INPIT