NUCLEOTIDE AND PROTEIN SEQUENCE OF SERRATE GENE OF VERTEBRATE AND METHOD BASED THEREON

• Main Authors: MANN ROBERT S, HENRIQUE DOMINGOS M P, ISH-HOROWICZ DAVID, GRAY GRACE E, MYAT ANNA M, ARTAVANIS-TSAKONAS SPYRIDON, LEWIS JULIAN H
• Format: Patent
• Language: English
• Published: 01.05.2008
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a vertebrate nucleotide sequence of a Serrate gene identified as a gene unit interactive with conjugative neuroplastic gene locus (Notch) of a Drosophila, an amino acid sequence of an encoded protein thereof, its derivative/analog and a method for the use thereof. SOLUTION: The invention provides the Serrate gene obtained from a vertebrate such as human and chicken, the purified Serrate protein, its derivative, the antibody against the protein, the pharmaceutical composition to use the above substances, and the diagnostic method for relating diseases. COPYRIGHT: (C)2008,JPO&INPIT