New immunostimulant condensed pyrimidine cpds

Condensed pyrimidine cpds. of the formula (I) and their hydrates and acid addn. salts of these cpds; and pyrimidine cpds. of the formula (IV) are new A is -(CH2)n- where n is 2, 3 or 4, or is -CH=CH-; R4 is H or opt. substd. phenyl; r is zero, 1, 2, 3 or 4, R1 is H or 1-5C alkanoyl; R2 is H, 1-5C al...

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Main Authors ATTILA MANDI, SANDOR TUBOLY, DANIEL BOZSING, GYORGYI KOVANYI LAX, EDIT BERENYI POLDERMANN, KAROLY MAGYAR
Format Patent
LanguageEnglish
Italian
Published 01.04.1992
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Condensed pyrimidine cpds. of the formula (I) and their hydrates and acid addn. salts of these cpds; and pyrimidine cpds. of the formula (IV) are new A is -(CH2)n- where n is 2, 3 or 4, or is -CH=CH-; R4 is H or opt. substd. phenyl; r is zero, 1, 2, 3 or 4, R1 is H or 1-5C alkanoyl; R2 is H, 1-5C alkanoyl or (III) R is H, 1-4C alkyl, 2-4C alkenyl, phenyl or phenyl-(1-3Cl), alkyl R3 is H; Y is halogen. Pref in (I), A is -(CH2)2- or -(CH2)3-; R4 is H or CH3; r is 1; R1 is H; R3 is H; R2 is H or -CS. NHC2H5. 7-Amino-5-imino -2, 3-dihydro -5H-thiazolo (3,2-a)pyrimidine; 8-amino-6-imino-3,4-dihydro- or 8-amino-6-imino-3-methyl- 2H,6H-pyrimido (2,1-b) (1,3)-thiazine; and N-ethyl-N1-(5-imino-2,3-dihydro-5H- thiazolo (3,2-a)pyrimidin-7-yl)thiourea are specifically specifically claimed.
Bibliography:Application Number: IT19870023272