Hliðstæð aðferð við að framleiða nýjar (1-fenýl-1-heterósýklýl)metanól- og (1-fenýl-1-heterósýklýl)metýlamínafleiður

• Main Authors: ALFRED RICHARD GREEN, BERNARD ROBIN BOAR, ALAN JOHN CROSS, DUNCAN ALASTAIR GRAY
• Format: Patent
• Language: Icelandic
• Published: 21.02.2000
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new derivatives of oxazolyl- or thiazolylmethanol of the general formula (I) where X means O or S; R2 means H; R2 means H or lower alkyl; W means O or NH; R3 means H, lower alkyl or lower acyl; A means phenyl furyl, thienyl, naphthyl, pyridyl or pyrrolyl possibly substituted with R6 where R6 means one or some groups taken among lower alkyl, halogen atom, lower alkoxy-group, CF3, OH, NO2 or NR4R5 where R4 and R5 mean independently H, lower alkyl or lower acyl, and pharmaceutically acceptable acid-additive salts under conditions that the following five compounds are not the subject of the present invention: 1-(4-methyl-5-thiazolyl)-1-phenylmethanol, 1-(2,4- -dimethyl-5-oxazolyl)-1-phenylmethanol, 1-(5-thiazolyl)-1- -phenylmethanol, 1-(4-oxazolyl)-1-phenylmethanol and 1-(2,4- -dimethyl-5-thiazolyl)-1-(2-chlorophenyl)-methanol. Compounds of the formula (I) elicite neuroprotective properties and can be used in medicine for treatment of patients with neurodegenerative disorders. Invention describes also a pharmaceutical composition based on the above indicated compounds. EFFECT: improved methods of synthesis, enhanced curative effectiveness of compounds. 12 cl, 58 ex