Novel methods for production of therapeutic mammalian cells and cell spheres and compositions of same

Disclosed herein are compositions, devices, methods, processes, and systems for culturing of large quantities of mammalian cells in suspension culture. Also disclosed are unique and surprising cell populations derived from the disclosed methods, processes, and systems. In many embodiments, the cells...

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Main Authors SCULL Erin, FOLEY Kevin, TANDESKI Terry, HEATON Will, ZURAWSKI Jeff, FARHANG Niloofar, RODRIGUEZ-GRANROSE Daniel, ERICKSON Isaac, SILVERMAN Lara
Format Patent
LanguageEnglish
Hebrew
Published 01.02.2024
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Abstract Disclosed herein are compositions, devices, methods, processes, and systems for culturing of large quantities of mammalian cells in suspension culture. Also disclosed are unique and surprising cell populations derived from the disclosed methods, processes, and systems. In many embodiments, the cells are cultured in suspension in liquid culture media that is agitated to maintain the cells in suspension, and agitation increases to maintain cells in suspension while growing and dividing to create cell spheres. The disclosed devices, methods, processes, and systems are useful in tailoring characteristics of the resulting cells based on characteristics of donor subject/initial cells. The disclosed cell populations are useful in treating subjects with cell based therapies in need thereof for various diseases and conditions.
AbstractList Disclosed herein are compositions, devices, methods, processes, and systems for culturing of large quantities of mammalian cells in suspension culture. Also disclosed are unique and surprising cell populations derived from the disclosed methods, processes, and systems. In many embodiments, the cells are cultured in suspension in liquid culture media that is agitated to maintain the cells in suspension, and agitation increases to maintain cells in suspension while growing and dividing to create cell spheres. The disclosed devices, methods, processes, and systems are useful in tailoring characteristics of the resulting cells based on characteristics of donor subject/initial cells. The disclosed cell populations are useful in treating subjects with cell based therapies in need thereof for various diseases and conditions.
Author HEATON Will
FOLEY Kevin
RODRIGUEZ-GRANROSE Daniel
FARHANG Niloofar
ZURAWSKI Jeff
SCULL Erin
TANDESKI Terry
ERICKSON Isaac
SILVERMAN Lara
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ZURAWSKI Jeff
SCULL Erin
TANDESKI Terry
ERICKSON Isaac
SILVERMAN Lara
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Snippet Disclosed herein are compositions, devices, methods, processes, and systems for culturing of large quantities of mammalian cells in suspension culture. Also...
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Title Novel methods for production of therapeutic mammalian cells and cell spheres and compositions of same
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