Bifunctional degraders of galactose-deficient immunoglobulins
An agent including a glycan-specific IgG antibody moiety, a cellular receptor binding moiety which binds to hepatocytes or other degrading cells through asialoglycoprotein (ASGPR) receptors of hepatocytes or other cell receptors which are on the surface degrading cells in a patient or subject, and o...
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| Main Authors | , , |
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| Format | Patent |
| Language | English Hebrew |
| Published |
01.11.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | An agent including a glycan-specific IgG antibody moiety, a cellular receptor binding moiety which binds to hepatocytes or other degrading cells through asialoglycoprotein (ASGPR) receptors of hepatocytes or other cell receptors which are on the surface degrading cells in a patient or subject, and optionally, a linker moiety connecting the glycan-specific IgG antibody moiety and the cellular receptor binding moiety. |
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| AbstractList | An agent including a glycan-specific IgG antibody moiety, a cellular receptor binding moiety which binds to hepatocytes or other degrading cells through asialoglycoprotein (ASGPR) receptors of hepatocytes or other cell receptors which are on the surface degrading cells in a patient or subject, and optionally, a linker moiety connecting the glycan-specific IgG antibody moiety and the cellular receptor binding moiety. |
| Author | DUBOWCHIK Gene M SPIEGEL David CALDWELL Reese M |
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| DocumentTitleAlternate | מפרקים דו-פונקציונליים של אימונוגלובלינים חסרי גלקטוז |
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| Title | Bifunctional degraders of galactose-deficient immunoglobulins |
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