Bcl xl inhibitory compounds having low cell permeability and antibody drug conjugates including the same

The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for synthesizing the ADCs, compositions comprising the inhibitors or ADCs, and various methods of using the inhibitors and ADCs.

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Bibliographic Details
Main Authors TAO Zhi-Fu, SHEN Xiaoqiang, SONG Xiaohong, BENNETT DAVID JONATHAN, DOHERTY George, WANG Xilu, ACKLER Scott L, WELCH Dennie S, MARIN Violeta L, WENDT Michael, FREY Robin R, SULLIVAN Gerard M, CULLEN Steve C, HAIGHT Anthony R, JUDD Andrew S, KUNZER Aaron, BOGHAERT Erwin R, SOUERS Andrew J
Format Patent
LanguageEnglish
Hebrew
Published 30.06.2021
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Abstract The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for synthesizing the ADCs, compositions comprising the inhibitors or ADCs, and various methods of using the inhibitors and ADCs.
AbstractList The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for synthesizing the ADCs, compositions comprising the inhibitors or ADCs, and various methods of using the inhibitors and ADCs.
Author SOUERS Andrew J
BENNETT DAVID JONATHAN
KUNZER Aaron
TAO Zhi-Fu
CULLEN Steve C
JUDD Andrew S
SHEN Xiaoqiang
FREY Robin R
HAIGHT Anthony R
SULLIVAN Gerard M
WENDT Michael
ACKLER Scott L
BOGHAERT Erwin R
MARIN Violeta L
DOHERTY George
SONG Xiaohong
WELCH Dennie S
WANG Xilu
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– fullname: ACKLER Scott L
– fullname: WELCH Dennie S
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– fullname: WENDT Michael
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– fullname: HAIGHT Anthony R
– fullname: JUDD Andrew S
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– fullname: BOGHAERT Erwin R
– fullname: SOUERS Andrew J
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DocumentTitleAlternate תרכובות מעכבות של bcl xl עם חדירות נמוכה לתאים ותצמידי נוגדן-תרופה הכוללים אותם
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DOHERTY George
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WELCH Dennie S
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Snippet The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for...
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Title Bcl xl inhibitory compounds having low cell permeability and antibody drug conjugates including the same
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